Saturday, September 20, 2025

Paolo Pasco- Filipino-American Jeopardy Champion

This posting is inspired by Paolo 8-day Winning Streak closed to 200K that ended yesterday  

Paolo Pasco: A Filipino-American Champion Changing the Game on Jeopardy!

As a long-time Jeopardy! fan, I’ve watched countless contestants stand behind that podium, clickers in hand, and face off in the ultimate test of knowledge and nerves. Every now and then, though, someone comes along who feels different — not just another trivia master, but a true game-changer. Paolo Pasco is one of those rare champions.

Paolo’s rise on Jeopardy! stunned fans. With his calm presence, quick recall, and razor-sharp wagering strategy, he quickly made his mark. But what makes his story even more inspiring — to me personally, and to so many others in the Filipino-American community — is that he’s not just a trivia genius. He’s a Filipino-American genius.

Born in 2000 and raised in San Diego, Paolo grew up with the kind of curiosity and intellect that later propelled him into the world of puzzles. He’s more than a contestant; he’s a professional puzzle constructor. His work has appeared in The New Yorker, The Atlantic, The New York Times, and beyond. For those of us who have struggled just to finish the Saturday crossword, it’s staggering to think that Paolo is one of the minds actually creating them. He even served as an assistant crossword editor at The Atlantic and has run his own puzzle site — shaping the very games that others labor over with pencil and eraser.

Paolo is also a Harvard graduate (Class of 2022, computer science). While at Harvard, he was profiled as a “Filipino-American puzzle constructor” who grew up in San Diego. That detail matters. Representation matters. As a Filipino-American myself, I know how meaningful it is to see someone who shares our heritage standing tall in spaces where we haven’t often been visible. Watching Paolo thrive on national television, while knowing he’s also innovating in the world of puzzles and games, fills me with pride.

Now based in New York, Paolo continues to shape the puzzle community while carrying the title of Jeopardy!champion — and possibly a future Tournament of Champions contender. His blend of intellect, creativity, and cultural representation reminds us that success is not one-dimensional. It is not just about winning games or collecting titles; it’s about breaking ground, opening doors, and showing what’s possible.

For me, Paolo’s story isn’t just about Jeopardy! — it’s about visibility, excellence, and pride. He has shown the world that Filipino-Americans aren’t just participants in the cultural conversation; we can be leaders, innovators, and yes, champions.

Here’s to Paolo Pasco: a name we’ll be hearing for a long time, both in the puzzle world and on that famous Jeopardy!stage. For additional details read:

https://www.djournal.com/lifestyle/arts-entertainment/jeopardy-5-things-to-know-about-champion-paolo-pasco/article_a37f0c60-7188-5d2a-a6c6-90667322be69.html

Meanwhile, 
A previously unknown Pablo Picasso portrait of his muse Dora Maar was unveiled in Paris on Thursday, ahead of its sale at auction house Drouot with a reserve price of eight million euros ($9.5 million).
Painted in 1943 and kept in private hands since 1944, Bust of a woman with a flowery hat has never been exhibited publicly. Specialists described the oil-on-canvas work as “exceptional” and a milestone in Picasso’s career.
The portrait depicts Maar, a French photographer and painter who inspired around 60 of Picasso’s works, including The Weeping Woman and his wartime masterpiece Guernica.
The sale comes amid a slump in the Picasso market, with 2024 sales totaling $223 million, down from $597 million the year before.

Finally, Did you know that.....
The Philippines is one of 18 mega-biodiverse countries in the world, home to two-thirds of the Earth’s biodiversity and between 70% and 80% of the world’s plant and animal species.
It ranks fifth globally in the number of plant species and harbors around 5% of the world’s flora. Read the full article here: https://agriculture.com.ph/.../endangered-philippine.../

Friday, September 19, 2025

Some Hope for Me and Other CKD Sufferers

A Phase II trial of lubiprostone for Chronic Kidney Disease (CKD) is a multicenter, randomized, double-blind, placebo-controlled study published in August 2025 that included 150 patients, though the efficacy analysis included 116 patients. The trial evaluated lubiprostone's potential to reduce kidney function decline in patients with CKD, with the full results published in the journal Science Advances in late August 2025. 
Trial Details: 
  • Name: The LUBI-CKD TRIAL.
  • Design: Multicenter, randomized, double-blind, placebo-controlled.
  • Participants: 150 screened patients, with 116 included in the efficacy analysis.
  • Setting: Nine centers in Japan, from July 2016 to December 2019.
Findings and Implications:
  • PPrimary Goal:
    ThThe trial aimed to assess lubiprostone's effect on kidney function decline. 
  • MMechanism:
    LliLubiprostone was shown to increase spermidine production, which is thought to immprove mitochondrial function and provide a renoprotective effect. 
  • FFFuture Research:
    TThe research team plans to validate these findings in a larger Phase III trial and to exexplore biomarkers that predict treatment efficacy. 
  • PPotential:
    ThThis discovery suggests a new therapeutic strategy for managing CKD, focusing onon preventing the progression of kidney damage rather than just managing sysymptoms. 
Note: While the initial statement claims lubiprostone reduced decline in kidney function, this is likely referring to the preliminary findings and overall results of the Phase II trial, not necessarily a direct outcome of just 150 patients' observations.The study also noted the cohort's lack of diversity, which could affect the generalizability of the findings.
Meanwhile, 
Scientists have developed a groundbreaking universal cancer vaccine that trains the immune system to fight virtually any type of cancer. Unlike traditional therapies that target specific tumours, this revolutionary vaccine activates a broad immune response, allowing the body to recognise and attack multiple cancer types effectively.
Preclinical studies in mice have shown astonishing results, with tumours—including those resistant to conventional treatments—being eliminated. When combined with immune checkpoint inhibitors, the vaccine’s effectiveness skyrockets, offering new hope for patients battling aggressive or hard-to-treat cancers.
This innovation represents a massive leap forward in cancer treatment, moving from personalised, high-cost therapies to a potential standardised solution that could be accessible worldwide. Scientists are now preparing for human clinical trials, aiming to confirm these results and transform the future of oncology.
The universal cancer vaccine has the potential not only to save millions of lives but also to change the way we fight cancer forever. The era of a truly global, immune-powered defense against cancer may finally be within reach.
Finally, Did you know that.....
The Philippines was nearly self-sufficient in rice before the Marcos era? By the late 1960s, strong harvests and early Green Revolution gains gave the country near self-reliance.
But during the Marcos years, corruption in the fertilizer industry, mismanaged agricultural policies, and weak rural investment led to declining productivity. As a result, the Philippines shifted from near self-sufficiency to being one of the world’s top rice importers—a status it still struggles with today.

Thursday, September 18, 2025

Jimmy Kimmel and Stephen Colbert on the Fragile Edges of Free Speech

This posting is inspired by yesterday's suspension of the Jimmy Kimmel TV Talk Show on ABC 

Jimmy Kimmel, Stephen Colbert, and the Fragile Edges of Free Speech

Freedom of speech in America has always lived in tension with power. We like to think of the First Amendment as an unshakable shield, guaranteeing that no matter how offensive, satirical, or politically charged our words may be, the government cannot silence them. And yet, every so often, a case comes along that tests just how strong that shield really is.

The suspension of Jimmy Kimmel Live! after Kimmel’s remarks about Charlie Kirk’s assassination is one of those moments.

Kimmel and the Weight of Words

Kimmel’s monologue was blunt, even scathing. He accused conservatives of trying to distance themselves from Kirk’s killer while simultaneously exploiting the event for political theater. That kind of commentary is classic late-night fare — sharp, partisan, designed to provoke laughter and discomfort in equal measure.

But this time, the consequences came fast. The FCC Chair, Brendan Carr, openly threatened broadcast affiliates with regulatory action if they aired Kimmel’s words. Nexstar, a powerful group of ABC affiliates, quickly dropped the show. Disney’s ABC followed, pulling Kimmel off the air indefinitely.

What troubles me here is not whether one agrees or disagrees with Kimmel’s words. It’s that the machinery of government regulation — the FCC’s licensing power — was invoked as a weapon against political commentary. That should send a chill down anyone’s spine.


Colbert’s Brush With the FCC

This isn’t the first time late-night comedy brushed up against the limits of official tolerance. Back in 2017, Stephen Colbert faced a wave of FCC complaints after a crude joke about Donald Trump and Vladimir Putin. The FCC said it would “review” the matter, but ultimately no sanction followed.

Why? Because Colbert’s joke, however vulgar, aired after 10 p.m. (the “safe harbor” for indecency) and, more importantly, it was satire — protected political speech, not obscenity. Courts have long held that satire and opinion, especially about political figures, occupy the “core” of the First Amendment.

Colbert’s case ended as a reaffirmation of free expression. Kimmel’s case, so far, feels more like a warning.


The Difference That Matters

Both Colbert and Kimmel live in the same legal universe. They are broadcast personalities, subject to the FCC’s rules. They both trafficked in sharp political commentary. Yet the response was starkly different.

  • Colbert: Investigated, but ultimately shielded by precedent and public tolerance.

  • Kimmel: Pulled off air under the shadow of license threats.

The distinction isn’t about the law so much as about power and will. The FCC technically has limited authority over content — mostly around indecency, obscenity, and knowingly false “news distortion.” Kimmel’s remarks don’t neatly fit any of those categories. They were political opinion, not news. But a regulator’s threat, even if legally shaky, is often enough to make broadcasters fold.

That’s where the danger lies. The appearance of censorship, the risk of reprisal, is sometimes as effective as censorship itself.


The Chilling Effect

Free speech isn’t just about what’s written in court decisions. It’s about what people feel safe to say. When networks see a comedian suspended after a regulator’s threat, they internalize the lesson: play it safe. Avoid sharp commentary. Don’t risk the license.

This is the chilling effect at work. Speech doesn’t have to be banned outright to wither; it can die quietly in boardrooms and affiliate offices, smothered by the fear of government retaliation.


Why This Matters

If Colbert’s case showed that satire could still survive the outrage cycle, Kimmel’s case suggests that times have changed. Political speech — the most protected category of expression under our Constitution — is now at risk of being muzzled, not through legal judgments but through regulatory intimidation.

The First Amendment was designed to protect us against precisely this kind of abuse. It was meant to ensure that political commentary, even when offensive, even when uncomfortable, could not be punished by those in power. But what happens when power doesn’t need to win in court — when the mere threat is enough to silence?


What Comes Next

The real question is not just what happens to Jimmy Kimmel, but what happens to everyone who dares to speak freely on air. If regulators can target late-night comedians, could local broadcasters tone down investigative reporting? Could journalists soften coverage of political figures to avoid the FCC’s glare?

We may be entering a new era where the “safe harbor” for satire and commentary shrinks — not because the law changed, but because fear did. And once fear reshapes the media landscape, it’s hard to roll back.

If we want freedom of speech to remain more than a slogan, we have to defend it not only in courtrooms but also in cultural practice. That means demanding courage from broadcasters, accountability from regulators, and vigilance from all of us.

Because in the end, free speech survives only if enough people are willing to risk speaking freely.


Meanwhile, I asked my Virtual Assistant if what happened to Kimmel and Colbert may also happened to Jimmy Fallon, Another late night Show on NBC.
Here's what I learned: It’s hard to say for sure whether Jimmy Fallon will be next, but there are several factors that suggest it's a possibility — and some reasons why it might not happen. Here’s a look at the situation through a speculative/legal lens, based on what we know so far.

Evidence That It Might Happen

  1. Public pressure & precedent

    • Former President Trump publicly called for NBC to cancel shows hosted by Jimmy Fallon and Seth Meyers, following the suspension of Jimmy Kimmel Live!Reuters+1

    • There’s now a precedent: a late-night host (Kimmel) was pulled off air following regulator threats over political commentary. That sets an example that could encourage similar pressure on others. Reuters+2Business Insider+2

  2. Regulatory environment & FCC activism

    • The FCC Chair (Brendan Carr) has shown a willingness to criticize and threaten action against broadcasters for content he deems “misleading” or politically biased. The Kimmel episode makes clear that these threats can lead to real consequences (affiliates dropping the show, ABC suspending broadcast). Reuters+2Reuters+2

    • Conservative groups have also filed complaints against late-night hosts, including Jimmy Fallon — for ideological bias, for unequal political guest distribution, etc. TheWrap+1

    • There is growing scrutiny of how public airwaves are used by broadcasters. FCC licensing and public interest criteria give regulators some leverage, even if legal constraints remain. The concern over “news distortion” is becoming part of the conversation. WRAL.com+2The Guardian+2

  3. Fallon’s style and visibility

    • Fallon has historically been less confrontational politically than some of his late-night peers — less incendiary. That might give him more leeway, but also means that if he were to make a sharper political comment, it would stand out and possibly draw attention.

    • Because he hosts a major national broadcast show (The Tonight Show on NBC), any controversy around him tends to have higher visibility and could draw regulatory or political interest quickly.


Evidence That It Might Not Happen

  1. Fallon’s relative moderation

    • Compared to Kimmel (in this instance) or some others, Fallon often skews more toward celebrity/entertainment material than extremely pointed political commentary. If he stays in that lane, there may be fewer triggers for regulatory or political backlash.

  2. Legal protections & constraints

    • As with Colbert, Fallon is protected by the First Amendment, especially if what he says is opinion/satire rather than false factual claims. Regulatory action (like license revocation) over political commentary is a high bar legally.

    • FCC rules traditionally emphasize indecency, obscenity, “safe harbor” times, and false news/distortion in more limited ways — the law has not been clearly established for punishing political commentary that is merely critical or satirical.

    • Private corporations (like NBC, the network) also have reputational and commercial incentives; even if regulation pressures intensify, NBC has to balance its business and public relations risks.

  3. Risk of backlash

    • If Fallon were targeted, there would likely be legal challenges, media outcry, and political pushback from those who see it as censorship. The public reaction to Kimmel’s suspension is already strong, especially among free-speech advocates. That acts as a counter-force.


Key Legal / Free Speech Considerations

  • Core political speech gets the highest protection under the First Amendment. Criticism of political actors, satire, commentary — so long as it doesn’t cross into incitement, defamation, or knowing false statements — are very difficult to legally suppress.

  • FCC’s regulatory powers are limited:

    • They can regulate indecency (especially during hours when children are likely to be watching), but that doesn’t seem relevant here.

    • They can in principle act against “distortion” or misleading statements, but enforcement of that is rare, controversial, and legally risky.

    • Threats of license revocation or fines over political commentary are novel and likely to be challenged under constitutional safeguards (due process, vagueness doctrine, viewpoint discrimination, etc.).

  • The chilling effect is a big factor: even without legal sanction, the fear of being targeted is enough to make hosts, networks, and advertisers more cautious. Much suppression of speech historically happens through this soft pressure rather than overt bans.


My Take / Prediction

Given all of the above:

  • It is plausible that Fallon could find himself under pressure — especially if he says something that draws similar regulatory or political criticism.

  • However, unless he crosses a line that is more clearly forbidden under FCC rules (e.g. knowingly false statement, defamation, or extreme indecency), it seems less likely that NBC would suspend him in the same way or that regulators would successfully force the network to do so.

So: Fallon is at risk, but there’s probably more buffer — more “wiggle room” — for him than there was for Kimmel in this particular moment.


Finally, My Food For Thought:  ABC decision over Kimmel comments about Charlie Kirk’s killing comes hours after Trump-appointed chair of US media regulator threatened broadcaster’s license.

Wednesday, September 17, 2025

Japanese Lifestyle Promotes Longevity

Japan has now reached an impressive milestone of having over 95,000 people aged 100 years or older. This reflects a profound success in healthcare, diet, and lifestyle choices that promote longevity. The emphasis on physical activity, mental wellness, and community engagement plays a major role in maintaining good health and well-being.
These centenarians often participate in activities like the traditional exercises shown in the image, a reflection of Japan's deeply rooted cultural values of staying active and connected. People in these communities don’t just live longer but enjoy healthier and more fulfilling lives. Their way of living is an inspiration for many across the globe.
The regular participation in community activities has a positive impact on not only physical health but also mental health. By coming together in group settings and forming close-knit social circles, individuals can remain mentally sharp and emotionally supported as they age. It’s a holistic approach to life that contributes to longevity.
One of the most significant factors contributing to this longevity is the balanced diet typical in Japan, which is rich in fish, vegetables, and traditional foods that support heart health and brain function. The diet, coupled with active living, helps to keep the elderly population free from common age-related diseases, making Japan one of the leading nations in life expectancy.
This combination of healthcare, diet, community, and lifestyle can undoubtedly be considered a powerful formula for living longer, healthier, and happier lives. Japan’s success in this area is a testament to the impact that societal structure and healthy habits can have on individual longevity

Meanwhile, 
In a breakthrough that could change medicine forever, French scientists have developed an artificial heart that never stops beating—removing the need for human donors.
The device, created by the French company Carmat, is powered by advanced sensors and biocompatible materials that mimic the natural functions of a real human heart. It pumps blood continuously and adjusts automatically to the patient’s activity level—whether they’re resting or exercising. Unlike traditional transplants, there’s no risk of rejection, no waiting lists, and no reliance on finding a matching donor.
This innovation could save the lives of tens of thousands of people worldwide who suffer from end-stage heart failure but never receive a transplant in time. Patients who have tested Carmat’s heart have been able to return to daily life with a level of freedom and confidence once thought impossible.
If successful on a wide scale, this invention could mark the beginning of a future where “forever hearts” replace fragile transplants, giving countless people a second chance at life.

Lastly, My Photo of the Day- My 4 D's- Ditas, Dodie, David E ( RIP) and Dinah

Tuesday, September 16, 2025

Trumps Adversarial Actions Against Law Firms and Universities

This posting is inspired from my recent meal-time conversations with several new THD residents who were previously active in University Teaching and Research as their Profession prior to their retirement.      
Following his 2024 election, Donald Trump took unprecedented adversarial actions against specific law firms and universities, primarily through executive orders and funding threats
The policies, which began in early 2025, have been widely condemned by legal and academic organizations and are facing challenges in court. Some of the organizations targeted have capitulated to the administration's demands, while others have resisted. 
Actions targeting law firms
Since February 2025, the Trump administration has issued a series of executive orders (EOs) and memorandums targeting major law firms. The orders are seen as retribution for the firms' representation of political opponents, past government service by their attorneys, and involvement in cases that drew the administration's disapproval. 
Key adversarial actions include:
  • Targeting of specific firms: EOs specifically targeted firms like Perkins Coie, Jenner & Block, and WilmerHale, citing their past work related to matters such as the Russia investigation and the January 6th Capitol attack.
  • Punitive sanctions: The EOs included punitive measures, such as terminating government contracts, restricting firms' access to federal buildings, and suspending the security clearances of some lawyers.
  • Pressuring firms into deals: In exchange for lifting the sanctions, the administration has pressured some firms to make concessions. Paul Weiss, for instance, agreed to provide $40 million in pro bono work for causes aligned with the administration. Other firms, including Skadden and Kirkland & Ellis, have made similar deals.
  • A "chilling effect" on the legal profession: Critics, including the American Bar Association, argue these tactics have a "chilling effect," intimidating firms from representing clients the administration disfavors and undermining the rule of law. Some firms have reportedly scaled back their pro bono work in controversial areas. 
Actions targeting universities
The Trump administration has launched a broad campaign to reshape higher education, using funding threats and legal investigations to compel universities to adopt policies aligned with the administration's agenda. 
Key adversarial actions include:
  • Targeting Diversity, Equity, and Inclusion (DEI) programs: A January 2025 executive order instructed federal agencies to terminate DEI programs at universities receiving federal funding. Institutions that do not comply face the loss of federal money.
  • Weaponizing civil rights investigations: The administration has used the Education Department's Office for Civil Rights (OCR) to investigate dozens of universities for alleged antisemitism and DEI-related practices. In March 2025, it cut $400 million in federal funding to Columbia University and froze billions from Harvard, alleging violations of federal law.
  • Influencing academic policy: The administration's demands extend beyond funding to influence university operations, admissions, and curricula. Some universities have entered agreements with the White House to resolve investigations, while others, like Harvard, have sued.
  • Restricting international students: The administration has revoked student visas for foreign nationals involved in protests and attempted to ban international students from attending certain institutions, though some of these efforts have been challenged in court.
  • Accreditation reform: In April 2025, an EO directed the overhaul of the higher education accreditation system, empowering the Education Secretary to hold accreditors accountable for schools that do not meet the administration's standards. 
Responses to the policies
  • Legal challenges: Several law firms and universities, including Perkins Coie, Jenner & Block, WilmerHale, and Harvard, have filed lawsuits challenging the administration's executive actions. In several cases, federal judges have temporarily blocked the EOs. The American Bar Association has also sued the administration over its actions targeting law firms.
  • Concessions and concerns: Some targeted institutions have made concessions to the administration, fearing the financial and operational consequences of further adversarial action. This has raised concerns about academic freedom and due process.
  • Widespread condemnation: The policies have faced broad condemnation from various groups, including academic organizations, legal scholars, and civil rights advocates, who argue the actions undermine core constitutional principles and academic freedom. 
  • Personal Note: I came to the US in 1960 as a Graduate Student from 
  • the Philippines. After My Ph.D. graduation in Pharmaceutical Chemistry,
  •  I decided to stay/live here in the US.     
  • Finally, Did you know that..... 

  • The Philippines’ national dish, adobo, isn’t really Spanish at all?
    🍲
    While the word adobo comes from the Spanish adobar (“to marinate”), the technique of stewing meat in vinegar and salt was already being practiced by Filipinos long before colonization. This method wasn’t just for flavor—it was a natural way to preserve food in the tropical climate.
    Historians also note that Chinese traders influenced its development by introducing soy sauce, which later blended with vinegar to create the adobo we know today. So while Spain gave the dish its name, the recipe is a true Filipino original with deep pre-colonial and Asian roots.